TB Gold Quantiferon

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Interpreting TB Gold Quantiferon results

Interpretations

 

NIL TUBE in IU/mL ANTIGEN TUBE MINUS NIL TUBE in IU/mL FINAL RESULT INTERPRETATION
< = 8.00 <0.35

> = 0.35 & <25% of Nil tube

> = 0.35 & > = 25% of Nil tube

Negative

Negative

Positive

M. tuberculosis infection unlikely

M. tuberculosis infection unlikely

M. tuberculosis infection likely

>8.00 Any result Indeterminate This may be due to excessive levels of circulating gamma interferon or the presence of heterophile antibodies

 

Description

What is TB Gold Quantiferon?

A TB Gold Quantiferon test is a screening test done to diagnose tuberculosis (TB). This test is suggested if you have symptoms of TB such as persistent cough, fever, and sudden weight loss. People who are at high risk for developing TB are those with HIV infection, weakened immune systems, and advanced age.

Tuberculosis is an infection that most often affects the lungs and is caused by a bacteria called mycobacterium tuberculosis. However, it can also affect other organs like your spine, brain, or kidneys. TB can spread from one person to another through the air. When a person infected with TB coughs, speaks or sings, TB bacteria can enter the air. People nearby can breathe in these bacteria and become infected. It spreads easily where people gather in crowds or where people live in crowded conditions. The disease may also affect those not treated properly for TB in the past.

An active TB infection is when TB symptoms are being experienced by the affected individual, however, a latent infection is when the TB organism is present in the individual’s body but there are no symptoms. People with latent TB infection are not infectious and cannot spread the infection to others. This individual, however, if left untreated, may develop an active infection in the future and may be able to transmit the disease.

TB Gold Quantiferon, also called QuantiFERON-TB Gold (QFT-G) T, is a modern alternative to the tuberculin test. It provides a highly specific and sensitive analysis of the condition. A positive result is a strong indicator of TB infection. However, this test cannot distinguish between active and latent TB infection, and therefore, the QuantiFERON Gold test is used in conjunction with risk assessment, radiography, and other medical and diagnostic evaluations.

Usually, no special preparation is required for a TB Gold Quantiferon. Any individual with an existing chronic illness or on specific medicine should discuss it with doctors to ensure maximum accuracy of the results. However, the timing of the test can also affect the accuracy of the results. If a person is tested too soon after their exposure to tuberculosis bacteria, they may have a false negative result. Doctors recommend testing at least 6 to 8 weeks after the exposure to TB.

Test result ranges are approximate and may differ slightly between different labs depending on the methodology and laboratory guidelines. Discuss your test reports with your doctor. Doctors may consider other factors, such as your health history, symptoms, medical conditions, and other test results to establish a diagnosis of TB disease. If the TB Gold Quantiferon test shows a positive result, follow-up testing and other clinical evaluations are used to determine whether the TB infection has progressed to active TB disease.

What is TB Gold Quantiferon used for?

A TB Gold Quantiferon test is done to:

  •  In case you have been exposed to tuberculosis.
  • In patients who have already had an infection with TB.
  • In patients who are habitual in using drug syringes.
  • Young age children, elderly people, and immunocompromised patients, since they have a high risk of progression of latent TB infection into active TB.
  • People who are in close contact with TB-infected patients.
  • Health care professionals taking care of TB patients.
  • People residing in high-risk settings such as near health care facilities or nursing homes etc.

What does TB Gold Quantiferon measure?

A Quantiferon TB Gold Test is conducted to detect the presence of Mycobacterium tuberculosis, the tuberculosis (TB) causing bacteria in an individual’s body. This test helps determine whether a person has a tuberculosis infection or not. The purpose of this test is to analyze an individual’s immune reactivity to Mycobacterium tuberculosis by measuring the amount of a specific protein called interferon-gamma (IFN-g) that is produced by a person’s T cells (a type of white blood cells).

If an individual is infected with tuberculosis, their T cells are much more likely to release interferon-gamma (IFN-g) when mixed with Mycobacterium tuberculosis antigens. This is why the QuantiFERON TB Gold blood test is prescribed to people exhibiting symptoms of tuberculosis.

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